Since 2019, RISE has supported lifesaving services in nearly 30 countries across Africa, Asia, Eastern Europe, and Latin America and the Caribbean.

• RISE is saving lives and improving health through direct life-saving service delivery programming and by supporting country governments to strengthen essential data systems, supply chain and commodity management, human resources for health, domestic resource mobilization, product introduction and market shaping, and other cross-cutting health system functions to accelerate transition to country ownership and self-reliance. Read more.

RISE advances the America First Global Health Strategy by working to improve health outcomes while strengthening health system preparedness, resilience, and self-reliance. Three key objectives support this goal:

• 1. Accelerate Improved Health Outcomes Through High-Quality, Life-Saving Service Delivery
  Enhance the coverage, quality, and effectiveness of evidence-based interventions for HIV/TB, maternal and child health, nutrition, and malaria. This will be achieved by scaling up lifesaving clinical and community-based services, strengthening provider capacity, and ensuring availability of essential commodities.

• 3. Enhance Preparedness and Resilience to Public Health Threats
  Increase the capacity of countries and health systems to prevent, detect, and respond to emerging health threats by strengthening surveillance systems, emergency response mechanisms, and outbreak management capabilities.

• 2. Support Durable, Resilient, and Integrated Local Health Systems
  Strengthen health systems by enhancing human resources for health (HRH), data and health information systems, optimizing supply chain management, and reinforcing laboratory service. Support country-led transitions toward self-reliance.

Through integrated and evidence-based approaches, RISE strengthens national health systems and accelerates the transition of health services to country governments by:

• Optimizing Service Delivery
  Flexibility, adaptability, and responsiveness guide RISE’s efforts to address emerging health threats and urgent health sector needs. The project operates through adaptable models that enable rapid, efficient, and effective response to U.S. government (USG) and country priorities. Working with national and sub-national governments, private sector partners, and community and faith-based organizations (FBOs), RISE applies data-driven performance tracking to deliver lifesaving programs efficiently. This approach supports market access and economic partnerships, advancing U.S. economic interests while driving health impact through innovation, new product introduction, and market shaping and development.

• Leveraging Technical and Operational Excellence
  RISE’s consortium brings together strong technical and operational teams with deep on-the-ground experience and access to an extensive network of experts. The RISE project has delivered strategic technical support across a wide arc of program areas and priorities—strengthening HIV, TB, malaria, mpox, and Marburg responses; supporting facility- and community-level interventions; and bolstering oxygen systems, laboratory networks, and surveillance capacities essential for global health security. All of this is woven together through deliberate, multisectoral coordination and integrated approaches to ensure countries can detect, respond to, and mitigate emerging threats with agility and confidence.

• Supporting Transition to Host Country Governments
  Planning for transition and handover to host country governments is integrated into RISE from the outset, ensuring that time-limited USG investments are leveraged for sustainable results. RISE strengthens data systems, commodity security and supply chains, and human resources for health, while mobilizing domestic resources to promote ownership and accountability among host country counterparts. These catalytic investments prepare governments for self-reliance and lasting impact.

• Advancing USG Foreign Policy Priorities
  Collaborative planning with USG and Ministry of Health stakeholders ensures alignment with U.S. foreign policy goals and the America First Global Health Strategy. Through integrated approaches across all technical areas, RISE promotes operational and strategic efficiency, prioritizing lower-cost, higher-efficiency models and delivering value for Americans and partner countries.

• Since 2019, RISE has supported lifesaving services in nearly 30 countries across Africa, Asia, Eastern Europe, and Latin America and the Caribbean.

• • RISE has provided nearly 200 subawards to non-US partner organizations
  • 4,000,000 people have received RISE-supported HIV testing services including 931,000 pregnant women
  • 95.3% of RISE-supported clients on antiretrovirals are virally suppressed
  • 75,000 health workers were trained in emergency and critical care
  • 30,000 health workers trained to prevent and control the spread of infection in health facilities
  • 9 countries with construction projects to improve emergency response or oxygen infrastructure